Peptide Manufacturing
Our peptide synthesis development and manufacturing services support a broad range of peptide therapeutics, including GLP-1 analogs, recombinant peptides, other high-volume and complex-structure peptides, from development through commercial cGMP supply, providing flexible solutions through a single trusted partner.
Peptide Types
From simple linear peptides to PPMO conjugates and GLP-1 analogs — our combined AJIPHASE™ and CORYNEX™ capabilities span the peptide therapeutic landscape.
Linear Peptides
Most peptide therapeutics can be manufactured using AJIPHASE™, our proprietary Tag-Assisted Liquid-Phase Peptide Synthesis (LPPS) platform. By performing synthesis in solution using a soluble tag, AJIPHASE™ supports efficient scale-up, broad sequence flexibility, and GMP manufacturing.
Cyclic Peptides
Cyclization chemistry for constrained peptides — head-to-tail, sidechain, and disulfide cyclization. Confirm specific chemistries in scope with the team.
Modified Peptides
AJIPHASE™ supports the manufacture of peptides with a wide range of chemical modifications, including lipidation, PEGylation, conjugation, and non-natural amino acids. Each process is designed around the properties of the molecule to deliver consistent product quality, scalability, and reliable commercial supply.
Complex sequences
AJIPHASE™ supports cyclic peptides, stapled peptides, conjugated peptides, and other modified sequences. Manufacturing strategies are tailored to the specific requirements of each molecule to optimize quality, scalability, and supply reliability.
GLP-1 analogs
AJIPHASE™ provides a scalable manufacturing solution for GLP-1 analogs and other high-volume peptide therapeutics. For selected molecules, CORYNEX™ recombinant expression technology can also be incorporated into a hybrid manufacturing strategy.
Long-chain peptides
AJIPHASE™ supports long peptide sequences through fragment-based synthesis strategies. For natural amino acid peptides requiring very large commercial volumes, CORYNEX™ recombinant expression technology offers an alternative manufacturing route.
Removing Barriers to Peptide Development
AJIPHASE™ is Ajinomoto Bio-Pharma Services’ proprietary liquid-phase peptide synthesis platform based on Tag-assisted chemistry using standard chemical reactors, supporting efficient scale-up while reducing solvent and reagent consumption. CORYNEX™ uses the Gram-positive bacterium Corynebacterium glutamicum to secrete peptides directly into the culture medium for efficient production tailored to each target.
GLP-1: Meeting the Demand for Metabolic Therapeutics
AJIPHASE™ supports GLP-1 manufacturing through fragment-based synthesis strategies that improve process efficiency and enable scale-up beyond conventional solid-phase approaches. For selected molecules, fermentation-based technologies, CORYNEX™ recombinant expression, can also be incorporated as part of a hybrid manufacturing strategy, providing additional flexibility to optimize cost, scalability, and long-term supply.
Analytical and Quality Systems
Ajinomoto Bio-Pharma Services provides integrated analytical development, quality control, and CMC support through dedicated in-house teams. Capabilities include method development and validation, impurity characterization, stability studies, and release testing using advanced analytical technologies. Combined with robust GMP quality systems and regulatory expertise, these capabilities support analytical and control strategies from development through commercial supply.
20+
Years of Peptide Synthesis Expertise
4
Sites Across Belgium & Japan
GOLD
EcoVadis Sustainability Certification
Development and Manufacturing Facilities
Four sites in Belgium and Japan providing flexible approaches to fit the unique needs of your specialized programs.
Commercial API production
Wetteren, Belgium
Wetteren provides GMP peptide manufacturing capabilities using AJIPHASE™, conventional liquid-phase synthesis, and flow chemistry technologies. The site supports commercial production, scale-up, and long-term supply of peptide therapeutics.
Peptide synthesis
Balen, Belgium
Balen supports commercial GMP peptide manufacturing and continuous flow chemistry technologies. Processes built for scale-up, sustainability, and long-term supply of peptide therapeutics.
AJIPHASE™ Production
Tokai, Japan
Japan serves as the center for AJIPHASE™ process development, analytical development, technology transfer, and GMP manufacturing. Integrated development, quality, and manufacturing teams support programs from early development through commercial supply.
recombinant Peptide expression
Kawasaki, Japan
CORYNEX™ strain, process, and analytical development is performed in-house at our facility in Kawasaki, Japan, with GMP manufacturing carried out by qualified partner CDMOs under our technical oversight.
Let’s Discuss Peptide Synthesis for Your Program
Chemical synthesis to commercial scale. Recombinant expression for complex peptides. One team from development to supply.
Frequently Asked Questions
What peptide types can Aji Bio-Pharma manufacture?
Ajinomoto Bio-Pharma Services supports the manufacture of linear, long-chain, cyclic, stapled, and other complex peptide therapeutics, including GLP-1 analogs. Manufacturing approaches are tailored to each molecule using AJIPHASE™ and, where appropriate, CORYNEX™ recombinant expression technology.
What is the difference between AJIPHASE™ and CORYNEX™ for peptides?
AJIPHASE™ uses Tag-Assisted Liquid-Phase Peptide Synthesis, while CORYNEX™ uses recombinant expression technology. Platform selection depends on peptide length, sequence composition, modifications, and commercial supply requirements. For some programs, both technologies can be combined as part of a hybrid manufacturing strategy.
Can Ajinomoto Bio-Pharma Services manufacture GLP-1 peptides at commercial scale?
Yes. AJIPHASE™ supports scalable manufacturing of GLP-1 analogs. Fragment-based synthesis strategies enable efficient production of peptides of approximately 40 amino acids, while CORYNEX™ technology can be incorporated into hybrid manufacturing approaches for selected programs.
What is your maximum peptide synthesis scale?
AJIPHASE™ can demonstrate cGMP manufacturing at scales exceeding 100 kg per batch using chemical reactors. Achievable scale depends on peptide characteristics and manufacturing equipment. CORYNEX™ recombinant expression technology is also available for selected high-volume peptides.
Do you support peptide-PMO conjugate (PPMO) synthesis?
Yes. Ajinomoto Bio-Pharma Services offers integrated peptide and oligonucleotide manufacturing capabilities, providing a single partner for PPMO development, manufacturing, and supply.