Small Molecule Manufacturing
We support our partners with deep expertise in the development and manufacturing of small molecule APIs and intermediates. Our services span the full product lifecycle, from early development through commercial manufacturing, with specialized process expertise and advanced technologies for challenging chemistry.
Our Specialized Services
For programs with specialized process, safety or sustainability requirements, we offer advanced capabilities designed to address challenging manufacturing needs and enable robust, scalable solutions.
Continuous Flow Chemistry
Advanced flow chemistry for hazardous, high-energy or heat-sensitive reactions where process control, safety and consistency are critical.
HPAPI Manufacturing
Dedicated high-potency manufacturing capabilities with OEB4/OEB5 containment, long-standing HPAPI experience and site-specific capacity to be confirmed.
Sustainable Chemistry
Programs for successful green-route development based on biocatalysis, water-based chemistry, selective chemistries, solvent recovery & biosolvents, precious group metals recovery.
One Partner, Every Stage
From late-stage development to commercial manufacturing and final API micronization, we act as one integrated partner across the small molecule lifecycle. The majority of our activities support Phase III and commercial products, where reliability, compliance and supply continuity are critical.
In parallel, we selectively engage in Phase I–II programs — where strategic route redesign and sustainability improvements unlock maximum value early on. Projects are seamlessly managed across batch and continuous flow, including process intensification where beneficial.
Beyond small molecules, we also integrate peptides and oligonucleotides within the same ecosystem — ensuring continuity, flexibility and performance at every stage.
What Sets Our Small Molecule Services Apart
Deep Expertise in Challenging Chemistry
We combine deep expertise in hazardous chemistries — such as azide, nitration and hydrogenation — with a highly solution-driven mindset. We proactively think alongside our customers, flexibly adapting to evolving needs to deliver safe, robust and scalable processes up to OEB5.
Trusted & Reliable for Over 50 Years
With over 50 years of experience, we are a trusted partner for reliable API supply at the highest quality standards. Our strong regulatory track record is matched by open, transparent communication — building long-term trust through consistent performance and close customer collaboration.
Innovative Approaches to Manufacturing
We combine advanced chemistry with innovative manufacturing and supply strategies. From continuous flow, biocatalysis and emerging technologies to in-house engineered equipment, PAT integration and dual sourcing strategies, we continuously redefine process performance, operational excellence and supply reliability.
Sustainability Leadership
Sustainability is embedded in both process design and manufacturing. We transform processes into more atom-efficient, lower-impact routes using advanced chemistry and continuous flow, supported by our proprietary EcoPass tool and sustainable operations practices, making us a strong partner for SBTi-driven organizations.
50+
Years API manufacturing experience
20
Years HPAPI experience
19
Successful FDA inspections
10,000 L
Maximum reactor size
>920 m3
Total reactor capacity across network
API Development and Manufacturing Services
Our support goes beyond scaling a process for commercial production. Through an Operational Excellence mindset, we continuously improve processes as they evolve, with a focus on yield, robustness, safety, sustainability and cost competitiveness. Our integrated teams provide the expertise and continuity to support programs from early development and scale-up through commercial manufacturing and ongoing process optimization.
OUr approach to continous Api improvement
Transformation Across the Full Lifecycle
We support API programs across the full lifecycle — not simply by scaling processes, but by continuously unlocking new value as products evolve. Driven by an operational excellence mindset, our teams proactively improve yield, robustness, safety, sustainability and cost competitiveness through structured continuous improvement programs.
We are particularly strong in transforming customer processes into fundamentally safer and more sustainable manufacturing routes, leveraging continuous flow, biocatalysis and atom-efficient chemistry, supported by dedicated process safety expertise and proprietary sustainability assessment tools.
Solving Your Most Challenging Chemistry
We bring deep process expertise and specialized solutions to help you develop,
scale and manufacture complex APIs and intermediates with confidence.
Customer Stories
Real programs. Real outcomes. Anonymized to protect customer confidentiality — source confirmed internal case data.
Top-10 Pharma: Faster Scale-Up, Better Process
A top-10 pharmaceutical company needed to rapidly scale an API program without compromising quality, safety, sustainability or time-to-market. Rather than simply transferring the process, ABPS challenged the route itself — identifying opportunities to improve manufacturability, robustness and environmental performance before scale-up.
Following a successful NPI introduction, our Operational Excellence mindset continued to unlock improvements in yield, process consistency and lifecycle economics. The outcome was not just a successful launch, but a more competitive, resilient and sustainable manufacturing process built for long-term commercial success.
Commercial Product: Cost Competitiveness Without Supply Risk
A commercial product facing increasing cost pressure required a more competitive manufacturing model without introducing supply-chain risk. Leveraging the ABPS Belgium–India network, we implemented for our customer an internal transfer to Vizag while retaining the same project management structure, process knowledge and quality standards.
The result was a lower-cost supply model, uninterrupted product availability and continued regulatory confidence — delivering both improved economics and the peace of mind of this long-term partner.
Frequently Asked Question
How do you manage technology transfer and project onboarding?
Every project starts with a structured kick-off that establishes clear objectives, responsibilities and timelines. From there, dedicated project management, biweekly governance meetings and agreed reporting keep all stakeholders aligned. Every campaign concludes with a joint performance review covering both technical outcomes and collaboration effectiveness. This Operational Excellence-driven approach ensures rapid knowledge transfer, transparent communication and continuous improvement from onboarding through commercial supply.
Will I have clear points of contact throughout the project?
Yes. Every customer benefits from two dedicated contacts: a Key Account Manager for commercial matters and a Project Manager for technical and operational execution. In parallel, direct interactions between customer and ABPS subject matter experts are actively encouraged. This combination of clear accountability and open communication enables faster decisions, stronger alignment and more effective problem solving throughout the project lifecycle.
Are there limitations to the types of projects you can handle?
Very few. ABPS has built its reputation on solving challenging chemistry problems. From hazardous reagents and highly potent compounds to quality-critical, safety-sensitive and environmentally demanding processes, we routinely support projects that push the boundaries of pharmaceutical manufacturing. By combining advanced containment, process safety expertise, continuous flow and biocatalysis, we can safely develop, scale and manufacture an exceptionally broad range of APIs and intermediates. The added advantage: customers often improve both manufacturing performance and sustainability metrics, supporting increasingly ambitious Scope 3 targets at the same time.
How do you ensure sufficient manufacturing capacity for my product?
Capacity planning starts with transparency. Through regular risk-adjusted forecasting and close customer collaboration, ABPS translates anticipated demand into long-term capacity strategies across its manufacturing network. This enables proactive resource planning while maintaining flexibility for changing market conditions. The result is a shared multi-year supply vision that minimizes supply risk, supports on-time-in-full delivery and gives customers the confidence to plan their business with certainty.
How do you approach analytical development and analytical support?
Analytical development is integrated from the earliest stages of every project. Depending on customer needs, ABPS can transfer existing methods or develop and validate them internally using an extensive analytical toolbox and advanced PAT capabilities. Because analytical expectations continue to evolve throughout development and commercialization, we focus on early alignment and transparent communication, helping customers reduce risk, avoid delays and maintain control over quality throughout the product lifecycle.